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Pityriasis rosea, a rash that lasts longer than expected | Incheon Pityriasis Rosea
Blog August 9, 2025

Pityriasis rosea, a rash that lasts longer than expected | Incheon Pityriasis Rosea

Dr. Yeonseung Choe
Dr. Yeonseung Choe
Chief Director

Incheon Pityriasis Rosea: Rashes that persist longer than expected

“It's called pityriasis rosea, but I was told it usually goes away in about two months. But for me, new ones keep appearing instead.”

Red spots scattered across the arms and sides remained. Initially it was just a single patch about 2cm in diameter, but within 4 days it had spread to the lower back, inner arms, and front of the thighs. The edges of the lesions were red, and the center was covered with thin scales, making the skin texture rough.

The itching worsened in the evening, disrupting sleep about 4~5 times per week. Taking antihistamines reduced the itching, but there was almost no change in the size or shape of the lesions. Within 10 minutes after showering, the borders of the lesions became more distinct, and even after a day or two, the redness did not easily fade.

In the blood test, the lymphocyte ratio was slightly low at 18%, and there was a history of blood pressure medication being changed 3 months ago. In this way, overlapping physical conditions and environmental factors were showing an atypical course.

Atypical course

In typical pityriasis rosea, after the initial lesion (herald patch) appears, it spreads systemically within 1~2 weeks and gradually disappears within 6~8 weeks. The cause is mainly attributed to HHV-6/HHV-7 reactivation, where the immune response creates inflammation at the epidermis-dermis boundary, then naturally resolves once immunity stabilizes.

In this case, the rash did not fade even after 8 weeks, and new lesions kept appearing. Drug-induced rash (ACE inhibitors, certain antibiotics, gold preparations, etc.), infections other than latent viruses, or autoimmune inflammation could be the cause.

From a Korean medicine perspective, this is a state where wind-heat has penetrated from the superficial layer into the blood level, fluctuating between the interior and exterior. When this happens, seasonal changes, stress, or fatigue become triggers for recurrence.

Why waiting alone won't solve it

If following the typical course, one should have entered the recovery phase by now. However, the rash area did not decrease, the itching repeated every night, and hyperpigmentation began to remain where scratched. While antihistamines relieved the symptoms, the color and size of the lesions remained unchanged.

That symptoms that would have improved within a few weeks in a simple allergic reaction are continuing suggests that the rash has not remained only on the skin surface but has taken root deeply.

From a modern medical perspective, it is necessary to differentiate drug-induced PR, persistent PR, and in rare cases, early-stage cutaneous T-cell lymphoma. From a Korean medicine perspective, both the exterior and the interior are affected, so simply cooling the exterior heat will not resolve the issue. The heat on the skin surface and the heat deep in the blood level must both be addressed.

Possible causes and interpretation

Causes can be broadly divided into three categories.

  • Drug side effects – Rashes can be triggered even weeks to months after taking medication. Improvement tends to occur when the causative drug is discontinued.
  • Viral reactivation – Triggered by immune suppression, overwork, lack of sleep, etc.
  • Autoimmune reaction – When immune regulation fails, rashes persist for extended periods.

In Korean medicine, this is interpreted as a state where wind-heat has remained dormant in the blood level, periodically surfacing. If only the exterior heat is relieved, symptoms may improve temporarily, but the rash will reappear.

Modern medical treatment considers topical steroids, phototherapy, and immunomodulators as appropriate for the situation. Korean medicine approaches use herbs with blood-clearing and detoxifying, blood-nourishing and wind-dispelling effects to reduce internal heat and inflammation.

Treatment and management approach

Persistent rashes cannot be resolved by treating only the surface. It is necessary to check and remove causative drugs, recent lifestyle patterns, and environmental factors as needed. Shower with lukewarm water and use moisturizer frequently to protect the skin barrier.

Adequate sleep, regular meals, and stress management are necessary for immune recovery.

Korean medicine treatment focuses on regulating both the exterior and the interior, dispersing wind-heat and calming heat in the blood level. For severe heat-toxin, Hwangnyeon (Coptis) and Geumhwa (Lonicera) are used; for persistent blood heat, Saengjihwang (Rehmannia) and Mokdanpi (Moutan bark) are utilized.

When cause investigation, simultaneous treatment of exterior and interior, and lifestyle management proceed in parallel, even long-persistent rashes can gradually subside. Ultimately, persistent pityriasis rosea deviates from the "it will heal if you wait" typical course, requiring proactive investigation and customized treatment.

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Dr. Yeonseung Choe

Dr. Yeonseung Choe Chief Director

I have met many patients who came after visiting multiple medical institutions and departments for persistent or recurrent conditions. Symptoms normally handled by different specialties—such as abdominal pain, headaches, palpitations, dizziness, and insomnia—may overlap in one person. Sometimes there is no clear improvement despite taking medication for each symptom, and being unwell gradually becomes part of daily life. In these cases, I look beyond individual diagnoses and examine how the symptoms connect and change together. Asking only about the most uncomfortable symptom today does not reveal the full course. I look at when the body first began to change and what happened after illness, surgery, childbirth, or starting and stopping medication. I also review changes in weight, diet, and sleep, then trace which symptoms improved with previous treatment and which remained. Test results, diagnoses, and the course of previous treatment are important for understanding the current condition. Clinical research in modern Korean medicine, physiological and pathological research in modern medicine, and observations recorded in classical Korean medicine texts offer different perspectives on the same body. Rather than fitting a patient into one perspective, I consider what each can and cannot explain and look for clues that connect symptoms and treatment histories that were previously considered separately.

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